VEGFA and glioblastoma: Bevacizumab (also known as rhMAb-VEGF and Avastin) is a recombinant humanized monoclonal antibody that binds all human VEGF isoforms and is approved for the treatment of colon, breast, non-small cell lung cancer, and glioblastoma [50-54] and also prolongs the time to progression of disease in metastatic RCC [55,56].