Since A/J Tsc2+/- mice have a higher average score per kidney at nine months of age than C57BL/6 Tsc2+/- mice at 12 months of age, these data show that the A/J Tsc2+/- strain has a significantly higher tumor burden than the C57BL/6 Tsc2+/- strain. Here, TSC2 is linked to neoplasm.