In 2000, Vogl et al. [28] analyzed with use of a newly developed ELISA based on highly purified and re-natured p53 the presence of anti-p53 AAbs in the sera of 113 patients with ovarian carcinoma, 15 patients with borderline ovarian tumor, and 117 patients with benign ovarian tumor. Here, TP53 is linked to ovarian benign neoplasm.