Likewise, Icam2 was reported as upregulated (1.9-fold) in the liver and downregulated (−3.1-fold) in the lung of mice infected with Y. pestis strain 201, whereas we found Icam2 to be upregulated (2.8-fold) in the liver (Table 3) and unaffected in the lung in response to infection with WT Y. pestis CO92 (data not shown). This evidence concerns the gene ICAM2 and infection.