IFNG and infection: Most notably, IFN-γ, which we found to be upregulated in the liver, spleen, and lung of WT Y. pestis CO92-infected mice (Supplementary Tables 2 and 3) and also identified as a critical signaling pathway based on Ingenuity analysis of the entire gene expression dataset (Figure 3), was reported as downregulated in Balb/c mouse lungs in response to infection with the 201 strain [21].