SIAH1 and esophageal cancer: Indeed, human SIAH-1 mRNA is 2.3 kb but an additional transcript of 2.5 kb was shown in placenta [5]; in MCF-7 cells, a SIAH-1 variant that encodes a 298 amino acid protein designated SIAH-1L was reported [30] whereas another variant named SIAH-1S encoding a 195 amino acid protein was detected in breast, Kidney and esophagus cancer tissues [31].