For example, the TAP [Treatment of Age-related Macular Degeneration with Photodynamic Therapy] and VIP [Verteporfin in Photodynamic Therapy] Study Groups [22] concluded that lesion size was a strong predictor of VA outcome based upon observed PDT treatment and outcome while the VISION trials [20] found that anti-VEGF treatment of early lesions (defined on the basis of the combined characteristics of size, lipid, scarring and time of presentation) had a positive impact on VA outcome. Here, VEGFA is linked to age-related macular degeneration.