Since glycolysis and mitochondrial oxidative phosphorylation are linked processes [16], and we have previously shown that LDH-A is critical in regulating glycolysis and growth of breast cancer cells [18], we reasoned that the increased expression and activity of LDH-A in Taxol-resistant cells may lead to an increase of glycolysis and a decrease of mitochondrial oxidative phosphorylation. The gene discussed is LDHA; the disease is breast cancer.