In this study, we showed that EBER1 suppressed p21cip1/waf1 in HL cell lines through down-regulation of p53, EGR1, and STAT1, and EBER1+ HL cell lines were more resistant to apoptosis induced by histone deacetylase inhibitors or proteasome inhibitors. Here, EGR1 is linked to Hodgkins lymphoma.