GPT and Hepatitis: Other serious immune-related adverse events included grade 3 to 4 aspartate aminotransferase/alanine aminotransferase elevation secondary to noninfectious hepatitis in 4 (8%) patients, adrenal insufficiency in 2 patients (4%, 1 grade 2 with evidence of hypophysitis on magnetic resonance imaging and 1 grade 3) patients, grade 2 conjunctivitis in 2 patients, and grade 4 lipase elevation secondary to pancreatitis in 1 patient.