In contrast, MOG-EAE in the C57BL/6 mouse results in less well demarcated demyelination which, after immunization with the T cell epitope MOG 35-55, is independent of humoral immune responses as revealed in μMT mice lacking mature B cells [57] and in models with deficiency for the complement component C3 or the C5a receptor [58,59]. The gene discussed is MOG; the disease is Peripheral demyelination.