MBP and brain ischemia: Using the paradigm of mucosal tolerance, however, we demonstrated that induction of a TREG response to the brain antigen myelin basic protein (MBP) prior to cerebral ischemia could prevent development of the deleterious autoimmune response to this antigen and improve outcome (as assessed 1 month after MCAO)[6] There are, however, documented concerns about the long term consequences of mucosal tolerance/immune deviation therapy [7-9].