In this study we considered MBP specific induction of IFN-γ as the marker for the TH1 response and MBP specific induction of TGFβ-1 as the marker for the inducible TREG response; animals that evidenced a TH1 response to MBP had worse outcome from stroke while those that evidenced a TREG response to MBP had better outcome. The gene discussed is MBP; the disease is Stroke.