CSF3 and ischemia: Our meta-regression, which was the first meta-regression analysis of a neuroprotective drug in animal stroke models, identified higher doses of G-CSF to be associated with significantly smaller infarct volumes for doses between 10 and 60 μg/kg body weight (infarct size reduction 0.8% per one μg/kg body weight increase in dose when applied within the first 6 hours and 2.1% per one μg/kg body weight increase in dose when applied later than 6 hours after induction of ischemia).