Two common single nucleotide polymorphisms (SNPs) in the coding region of the lysyl-oxidase-like 1 (LOXL1) gene on chromosome 15 have been identified and account for virtually all cases of XFS in several populations.9–12 While the SNPs confer susceptibility to XFS, not all people with the SNPs will develop the disease. Here, LOXL1 is linked to exfoliation syndrome.