The increased levels of urinary albumin secretion may represent a more generalized vascular damage than renal microvascular injury alone.2 During the past decade, the incidence of end-stage renal disease has risen dramatically, primarily due to an increase in the incidence of diabetes.3 Glomerular hyperperfusion and renal hypertrophy occurs in the initial phase after the onset of diabetes mellitus and are reflected by an increased glomerular filtration rate. This evidence concerns the gene ALB and diabetes mellitus.