TNFRSF10A and type 1 diabetes mellitus: An association between HLA class I alleles and type 1 diabetes were first discovered by serological typing in the early 1970s.[80, 81] Subsequently, a closer association was demonstrated between HLA DR3 and DR4 alleles with the type 1 diabetes.[82] The major histocompatibility complex (MHC) region on chromosome 6p21.31 (IDDM 1) is a major susceptibility locus for the common mulitfactorial form of type 1 diabetes, estimated to account for 40%-50% of λs.