A4 allele was associated with a susceptible haplotype, DR4-DQB1*0401, and A6 allele is associated with a protective haplotype, DR2-DQB1*0601, suggesting that the association of MICA with type 1 diabetes susceptibility may be due to linkage disequilibrium with class II haplotypes.[107, 108]. The gene discussed is MICA; the disease is type 1 diabetes mellitus.