Meta-analysis studies also revealed that the CTLA-4*G genotype is associated with type 1 diabetes.[120] Several population studies showed increased transmission of the G allele of a 49A->G polymorphism associated with type 1 diabetes.[121] Asian studies yielded significant and reliable linkage evidence for the susceptibility of type 1 diabetes.[11, 31, 119] Japanese study results showed a significant correlation between CTLA4 gene polymorphism and ICA 512 Ab.[122]. The gene discussed is CTLA4; the disease is type 1 diabetes mellitus.