Lp(a) was found to bind to tetranectin with higher affinity than Glu or Lys plasminogen.[17] Systemic atherosclerosis measured as the peripheral occlusive arterial disease is strongly associated with serum Lp(a) in both type 1 and type 2 diabetes mellitus.[18] The Lp(a) levels have also been suggested to play a pathogenic role in development of complications like gangrenous foot lesions in patients of diabetes mellitus.[19]. This evidence concerns the gene PLG and diabetes mellitus.