This strategy has been performed in BBS consanguineous families to detect new genes, such as BBS9 [13], BBS11 [11], and BBS12 [16]; in other retinal pathologies, such as Leber congenital amaurosis, this strategy allowed the identification of novel mutations in the LCA5 gene [21]. This evidence concerns the gene TRIM32 and Leber congenital amaurosis.