CDKN2A and melanoma: This is the first study to report on loss across the critical region of 9p in primary melanoma, although loss of CDKN2A coding for CDKN2A has been suggested by others to be associated with poorer prognosis (Cachia et al.,2000; Grafstrom et al.,2005) and loss of CDKN2A expression immunohistochemically correlates with histological invasion (Talve et al.,1997; Pavey et al.,2002).