This is consistent with previous studies which have shown that deletion at CDKN2A appears to be the major mechanism of CDKN2A inactivation in primary melanomas (Funk et al.,1998; Fujimoto et al.,1999; Rizos et al.,1999; Cachia et al.,2000; Straume et al.,2002; Zhang and Rosdahl,2004). Here, CDKN2A is linked to melanoma.