The specific cytotoxicity observed after co-cultivating PBMC with LB1319-MEL cells pretreated with the combination of hIFN-γ and GGTI-298, suggests that these melanoma cells develop the ability to induce a specific anti-tumor immune response in vitro, likely linked to the increased proliferation of specific CD8 T lymphocytes. Here, PGGT1B is linked to melanoma.