As histopathological examination of globes from mice with buphthalmos frequently demonstrated angle closure, we compared the iridocorneal angle histology of 20 Vav2/Vav3-deficient (Vav2−/−Vav3−/−) mice with wild-type mice at both 7 and 12 weeks of age. Here, VAV3 is linked to congenital glaucoma.