Based on preliminary transcriptional profiling results of human colon cancer samples, where a strong downregulation of a FAS-related receptor was observed (data not shown), along with published reports of compromised Fas-mediated apoptosis in colon cancer, ApcMin/+/Faslpr mice were generated to determine the effects of a Fas deficiency in the ApcMin/+ mouse model. The gene discussed is FAS; the disease is malignant colon neoplasm.