HTRA1 and age-related macular degeneration: Next, to define the extent of the haplotype structures and capture all variants in the region, we undertook a re-sequencing effort of a region spanning ∼100 kb, starting in the 3′-UTR of PLEKA and ending ∼20kb downstream of the 3′ UTR of HTRA1 in six individuals with a homozygous risk haplotype and six individuals with a homozygous protective haplotype, followed by assessment of association of each discovered variant with AMD in 200 AMD cases and 200 normal controls (Table 1, Table S1, Table S2).