P4HB and neurodegenerative disease: For example, several isomerases (triosephosphate isomerase 1 TIP1; glucose phosphate isomerase GPI, protein disulfide isomerase family A, member 3 and 6, PDI, proline 4-hydroxyase, P4HB) and oxidative stress proteins (e.g., peroxiredoxin) were identified as nitrosylated, among which SNO-PDI [40] and SNO-peroxiredoxin [39], [41] have been reported to serve as direct links between nitrosative/oxidative stress and neurodegenerative diseases.