Deficiency of FVIII results in bleeding disorder commonly known as hemophilia A. 9,31–33 We used a list of 27 peptides each 12 residue long selected against mAb Bo2C11 targeting the C2 domain of FVIII.31 Using the X-ray crystal structure of the C2 domain of FVIII34 (PDB id:1IQD), EpiSearch method predicted a potential epitope on the C2 domain of FVIII that correspond to a patch centered at the residue R2220 with the highest score (0.937). Here, F8 is linked to hemophilia A.