VEGF was up-regulated in a murine lipopolysaccharide (LPS)-induced ALI model, and the changes in the balance between VEGF, angiopoietin-1, and angiopoietin-4 after LPS exposure may modulate the influx of neutrophils, protein leakage, and alveolar flooding in ALI mice [39]. The gene discussed is ANGPT4; the disease is acute respiratory distress syndrome.