In addition, Viñals group have shown that Aspirin produces an increase of CD36, ABCA1,SR-BI expressions in THP-1 macrophages by a PGE(2)-dependent mechanism [19], but we have demonstrated that the scavenger receptor class BI and ATP-binding cassette transporter A1 increased in macrophage cells in response to the ASA treatments lonely, The uptakes of modified lipoproteins by macrophages are the early steps leading to the atherosclerosis [20]. The gene discussed is ABCA1; the disease is atherosclerosis.