However, there are restrictions in access to biological treatments imposed by the government with RA and PsA patients requiring to have a minimum of 20 tender and swollen joints (or four major joints including elbows, wrists, ankles, and knees) along with a CRP > 15 mg/L and/or an ESR > 25 mm/hour. The gene discussed is CRP; the disease is rheumatoid arthritis.