A recent report on outcomes of TNF blocker treatment in the South Swedish Arthritis Treatment Group Register has demonstrated similar results to our outcomes in this study with 26% of patients switching to a second TNF blocker with a 51% ACR20 and a 27% ACR50 response and a 13% switch to a third TNF blocker with a 35% ACR20 and a 18% ACR50 response [22]. The gene discussed is TNF; the disease is arthritic joint disease.