Additionally, previous reports have shown that polyoxygenatedsterols from the formosan soft coral Sinulariagibberosa significantly inhibit the upregulation of the proinflammatoryinducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) proteins ofLPS (lipopolysaccharide)-stimulated RAW264.7 macrophage cells and cytotoxic activityagainst HepG2 (human liver carcinoma), MCF-7, MDA-MB-23 (human breast carcinoma),and A549 (human lung carcinoma) cells [20]. Here, PTGS2 is linked to hepatocellular carcinoma.