The investigations on the only previously characterized TCF binding site (-859/-855), demonstrated its ability to recruit TCF-4 in SW480 human colon cancer [35], but not in Hec251 endometrial cancer cell line [34] where, on the contrary, SLUG expression seems to be under transcriptional control of β-catenin without the binding of Lef/Tcf factors at this site. This evidence concerns the gene HNF4A and malignant colon neoplasm.