Some of the trans-regulated genes were previously implicated in drug or alcohol addiction, including Pnlip (pancreatic lipase) [50], Homer1 (homer homolog 1 (Drosophila)) [51], Jun (Jun oncogene), Adhfe1 (alcohol dehydrogenase, iron containing, 1) [52], Ptprr (protein tyrosine phosphatase, receptor type, R) [53], Klf15 (Kruppel-like factor 15) [54,55], Nfkb1 (nuclear factor of kappa light polypeptide gene enhancer in B-cells 1) [26], Sox18 (SRY-box containing gene 18) [56,57], and Qdpr (quinoid dihydropteridine reductase) [58,59]. Here, ADHFE1 is linked to Addictive alcohol use.