Aberrant promoter methylation in various tumour suppressor genes is also involved in human gastric cancer and oesophagus carcinoma [8-10] and the epigenetic silencing linked this aberrant de novo methylation of CpG islands to the overexpression of the DNMT-3 family (DNMT3A and DNMT3B). The gene discussed is DNMT3A; the disease is carcinoma of esophagus.