SMAD4 and colorectal carcinoma: Among the CRC genes established by Sjöbolm et al [23], the most commonly deleted in our samples were EPHB6, EXOC4 (SEC8L1), GNAS, MLL3, and TBX22. The most commonly amplified genes were HAPLN1(CRTL1), ADAM29, SMAD2, and SMAD4 (Table 3).