Several independent reports proposed that KLF6 is a tumor suppressor gene product due to downregulation of KLF6 expression or frequent somatic inactivating mutations were found within the klf6 gene in prostate carcinoma, colorectal tumors, glioblastoma, hepatocellular carcinoma and lung-derived tumors [8], [9], [10], [11], [12], [13], [14], [15]. The gene discussed is KLF6; the disease is hepatocellular carcinoma.