Although we have analyzed a small number of cases, in this report we further suggest that KLF6 is nuclear expressed in a significant percentage of ERBB2-overexpressing ductal breast tumors, and this nuclear stain pattern may be related to the malignancy and aggressiveness together with ERBB2-overexpression in early stage and small ductal breast tumors because of the presence of metastatic event in lymph nodes of patient harboring this tumor type. Here, KLF6 is linked to neoplasm.