HLA-G and hypercholesterolemia, familial, 1: To conclude, Based on our mutational analysis in HLA-G and our in situ observation of FHC as compared to conformed HLA-G in placental tissue we suggest that too much inhibition by HLA-G is dangerous and that the specific interaction of HLA-G with only one inhibitory receptor LIR-1 is to generate a situation in which only a fraction of NK cells expressing LIR-1 are inhibited.