ATP8B1 and benign recurrent intrahepatic cholestasis: Mutations in ATP8B1 result in cholestatic disease with an autosomal recessive mode of inheritance, and ranging in severity from mild and episodic (benign recurrent intrahepatic cholestasis, BRIC1) to chronic and progressive (progressive familial intrahepatic cholestasis; PFIC1) [1], [8], [9].