However in Schizosaccharomyces pombe eIF3f is essential for viabilityand depleting eIF3f remarkably decreases global protein synthesis in fission yeast[21].eIF3f overexpression has been associated with inhibition of HIV-1 replication [22] andwith activation of apoptosis in melanoma and pancreatic cancer cells [23]. The gene discussed is EIF3F; the disease is familial pancreatic carcinoma.