LAMB2 and myelodysplastic syndrome: WT mice with sustained MDS-like symptoms beyond 5 months after the last irradiation had increased BM angiogenesis, as determined by quantification of laminin staining in BM sections and also by quantification of collagen IV and laminin in whole BM extracts (since laminin and collagen IV are components of the vessels basement membranes), suggestive of disease progression.