Moreover, loss of function alleles, such as R151C, R160W, R142H, and D294H, which alter the ability to bind α-MSH and/or activate adenylyl cyclase, lead to increased sensitivity towards the cytotoxic effects of UV radiation and could be strongly associated with an increased risk to develop all forms of skin cancer including melanoma [62]–[68]. Here, STAMBP is linked to skin neoplasm.