This induction of cytotoxicity was associated with the increased expression of genes characteristic for the function of cytotoxic T lymphocytes since we detected granzyme B+CD8+ T cells in tumor-draining lymph nodes of wt mice injected with 25,000 tumor cells whereas CD8+ T cells expressing cytotoxic markers were neither detectable in tumor-draining nor contra-lateral lymph nodes of C57BL/6Je/e mice (Figure 4D). The gene discussed is CD8A; the disease is neoplasm.