Because 1) the concentration of E2 is not constant through the menstrual cycle, but rather fluctuates from the peak follicular phase serum E2 level of 1 nM to 0.7 nM in the luteal phase, and 2) E2 has dramatic effects on sensitivity to hERG block within this range, it stands to reason that susceptibility to drug-induced arrhythmia by hERG block may vary through the menstrual cycle. The gene discussed is KCNH2; the disease is Arrhythmia.