We now report that TWEAK activates NFκB2 and RelB and induces the expression of CCL21a mRNA and CCL21 protein in cultured murine tubular epithelial cells and in healthy kidneys and that TWEAK antagonism reduces tubular CCL21 and lymphocyte T infiltration in folic acid-induced AKI. The gene discussed is TNFSF12; the disease is acute kidney injury.