Multi-functional (IFN-γ and IL2) responses to pp65 and IE were also measured in a subset of subjects (21 subjects who were CMV-seropositive/HIV-seronegative, 20 subjects who had chronic untreated HIV infection and 60 subjects who were on antiretroviral therapy and had undetectable plasma HIV RNA levels) (Figure 3). The gene discussed is IL2; the disease is HIV infectious disease.