CD4 and HIV infectious disease: As compared to the CMV-seropositive, HIV-seronegative group, untreated participants with a recent HIV infection (n = 77) had a higher median frequency of pp65-specifc IFN-γ bright CD8+ T cells (0.31% vs. 0.67%, respectively, P = 0.02) and a similar median frequency of pp65-specifc IFN-γ bright CD4+ T cells (0.15% vs. 0.22%, P = 0.15; Figure 2).