While the expression of many ORGs and infection regulated genes, such as the nlp, cnc, and clec genes, exhibited concordance in their regulation under osmotic stress and infection conditions, some genes, such as the organic osmolyte accumulation enzyme gpdh-1, which encodes a glycerol-3-phosphate dehydrogenase, was strongly upregulated by osmotic stress but downregulated by most models of infection. The gene discussed is NINL; the disease is infection.