IGF2 and fetal growth restriction: Furthermore, we analyzed methylation status at four known imprinted regions on chromosome 11, some of which have been shown to harbor small changes in methylation in subjects with IUGR (the IGF2 differentially-methylated region (DMR), the H19 DMR and promoter region, and the KCNQ1 DMR) [25], [45] but found no detectable differences in the IUGR group compared to controls in this particular cell type (data not shown).