This network is functionally associated with cancer, cellular development, cellular growth and proliferation (Figure S4), and is centered on a number of transcription factors and growth hormones (e.g. NCOR2, GH1, TGFβ1, HNF4A), and TP53 which shows altered DNA methylation in renal tissue of IUGR rats in adult life [26]. The gene discussed is TGFB1; the disease is fetal growth restriction.