PTGS2 and Miyoshi myopathy: Based on the relevance of the COX-2 and EGFR pathways in MM [4,5,17,18] and the overlap between the two pathways [15], we performed studies to characterize five MM cell lines for COX and EGFR signalling and to analyze their response to COX-2 and EGFR inhibitors as single agent or in combination.