Confirming the protective anti-inflammatory effect of n-3 PUFAs, transgenic fat-1 mice expressing a gene encoding an n-3 fatty acid desaturase which enables production of n-3 from n-6 PUFAs, exhibit low NFκB activity, reduced levels of TNFα and IL-1β, and are protected from colitis [25]. The gene discussed is TNF; the disease is colitis.