Cluster 2b displayed a profile diametrically opposite to that of normal pancreas or chronic pancreatitis and was characterized by upregulation of ISG and IIP genes, while all IFN (including IFN-alpha4,5,7,17, IFN-beta1, IFN-omega1) and several IFN receptor genes (including IFN-alpha, beta and omega receptor 1, IFNalphabeta and omega receptor 2) were down regulated. This evidence concerns the gene IFNA1 and chronic pancreatitis.