As a consequence of the acceleration inIAP cleavage, the compounds were shown to inhibitIGF-I-stimulated phosphorylation of keysignaling molecules including Shc and ERK1/2, andthis in turn was associated with a decrease inIGF-I-stimulated cell proliferation.Identification of these compounds that utilizethis mechanism has the potential to yield noveltherapeutic approaches for the prevention andtreatment of vascular complications associatedwith diabetes. Here, MAPK3 is linked to diabetes mellitus.