PLCG2 and autoimmune disease: In summary, the importance of PLCγ2 in osteoclasts [15], [16] and neutrophils [14], [20], in conjunction with its role in DC-mediated T cell activation here discussed, positions the molecule as a point of convergence between bone and immune systems in complex pathologies such as RA and other autoimmune diseases characterized by an interplay between bone and immune cells.