AKT1 and neoplasm: HER2/neu has emerged as a key target for anticancer drugs due to its intrinsic involvement in the phosphatidylinositol-3-kinase-Akt/protein kinase B (PI3K-Akt) and the mitogen-activated protein kinase (MAPK) pathways, both of which suppress apoptosis and promote tumor cell survival, gene transcription, angiogenesis, cellular proliferation, migration, mitosis, and differentiation.[7] Three important classes of anti-HER2/neu therapeutics include: mAbs directed against extracellular ligand-binding and dimerization epitopes, tyrosine-kinase (TK) inhibitors and Hsp90 inhibitors.