A mouse strain, wrinkle-free (wrfr), containing a spontaneous mutation that abrogates Fatp4 expression, and Fatp4-KO mice display features of lethal dermatology, such as tight, thick, shiny skin and a defective skin barrier, and die shortly after birth, symptoms that are strikingly similar to those of a human skin disease called restrictive dermopathy [3], [4], [5]. This evidence concerns the gene SLC27A4 and restrictive dermopathy.