The majority of the upregulated genes were simultaneously downregulated in female PD alone (Figure 2A, Table 2), including several genes that are associated with pathways related to PD pathogenesis such as ST13, MAPT, XPO1, SLC11A2, DNAJC7, KCNN3, APBA2 and TNS1. This evidence concerns the gene APBA2 and Parkinson disease.